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Most are gastrointestinal, including nausea, vomiting, diarrhea, constipation, or abdominal discomfort, but some symptoms may signal dehydration, kidney stress, gallbladder disease, pancreatitis, hypoglycemia, or another problem that requires medical evaluation

It signals the body to hold onto muscle tissue even as overall body weight decreases

Laboratory investigation typically includes comprehensive metabolic panel, magnesium level, creatine kinase (if muscle injury is suspected), and possibly vitamin D level